METHODS OF TREATMENT WITH MYOSIN MODULATOR

Disclosed herein are methods of treatment comprising administering a therapeutically effective amount of a myosin modulator or a pharmaceutically acceptable salt thereof to a subject in need thereof and diagnostic methods useful in connection with those treatments. Due to observations unfolding in c...

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Main Authors ZHANG, David, DEL RIO, Carlos L, CARLSON, Timothy, LAMPL, Kathy L, MCDOWELL, Robert, KANE, Brian Edmund, FANG, Liang, HENZE, Marcus Patrick, LAMBING, Joseph, LI, Wanying, SEMIGRAN, Marc J, AUBELE, Danielle L, DESAI, Milind Y, FERNANDES, Sarah, NISSEN, Steve, MEALIFFE, Matthew Edwards, EDELBERG, Jay M, SEHL, Louis Charles, MA, Grace Yanfei, SEHNERT, Amy
Format Patent
LanguageEnglish
French
German
Published 13.12.2023
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Disclosed herein are methods of treatment comprising administering a therapeutically effective amount of a myosin modulator or a pharmaceutically acceptable salt thereof to a subject in need thereof and diagnostic methods useful in connection with those treatments. Due to observations unfolding in clinical trials with mavacamten and with mavacamten and other myosin inhibitors in the pre-clinical setting, new insights into how myosin inhibitors can be used beneficially to impact the disease state of HCM and other diseases are provided herein.
Bibliography:Application Number: EP20200884325