2-OXOTHIAZOLIDIN-4-ONE DERIVATIVES ACTIVE AS TRANSTHYRETIN LIGANDS AND USES THEREOF

Compounds of formula (II) are provided for stabilizing protein transthyretin (TTR) and inhibiting amyloid fibril formation, for example, transthyretin-mediated amyloid fibril formation, and for treating, preventing, or ameliorating one or more symptoms of amyloid diseases, for example, transthyretin...

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Main Authors PONTES MEIRELES FERREIRA DE BRITO, Rui Manuel, CABRAL CARDOSO LOPES, Ana Lucia, VIEIRA SIMÕES, Carlos Jose, DA SILVA VICTOR, Bruno Lourenço, LOURENÇO DE ALMEIDA, Zaida Catarina, VASCONCELOS DIAS DE PINHO MELO, Teresa Margarida, OLIVEIRA NASCIMENTO, Bruno Filipe
Format Patent
LanguageEnglish
French
German
Published 20.07.2022
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Compounds of formula (II) are provided for stabilizing protein transthyretin (TTR) and inhibiting amyloid fibril formation, for example, transthyretin-mediated amyloid fibril formation, and for treating, preventing, or ameliorating one or more symptoms of amyloid diseases, for example, transthyretin-related amyloidosis (ATTR).
Bibliography:Application Number: EP20210192238