FAST AND EFFECTIVE PURIFICATION METHOD IN DERMAL FILLER PRODUCTION

• Main Author: OYTUN, Faruk
• Format: Patent
• Language: English; French; German
• Published: 15.06.2022
• Subjects: AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; CHEMISTRY; COMPOSITIONS BASED THEREON; COMPOSITIONS OF MACROMOLECULAR COMPOUNDS; DERIVATIVES THEREOF; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; GENERAL PROCESSES OF COMPOUNDING; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METALLURGY; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; ORGANIC MACROMOLECULAR COMPOUNDS; POLYSACCHARIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; THEIR PREPARATION OR CHEMICAL WORKING-UP; WORKING-UP

The invention is a purification method required for a dermal filler production process. The object of the invention is to save considerable time and to effectively remove the residual cross-linking agent in the formulation, in contrast to conventionally used purification methods. After the production of cross-linked dermal filler gels, the particle sizes of the gels are reduced to approximately 500-2000 microns with the help of a homogenizer, then washed 7 more times with PBS solution during one hour in each washing, then filtering, bringing the gels to the desired particle sizes, adding Lidocaine HCl to the final mixture to provide an anesthetic effect, adjusting the pH of the final mixture to 7, filling 1 ml syringes under vacuum and performing steam sterilization of the filled syringes.