EYE DROPS BASED ON A STERILIZABLE LIPOSOMAL FORMULATION BASED ON CURCUMIN AND OPHTHALMIC USE THEREOF

A liposomal formulation with curcumin, where the amount of curcumin varies from 0.025% to 0.050% by weight of the total weight, is stable over time, even without preservatives and is sterilizable by filtration on 0.2 μm filter, so as to be usable as eye drops. Eye drops based on this liposomal formu...

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Bibliographic Details
Main Authors VELLANTE, Marco, SODO, Eugenio, CAVALLO, Giovanni, FOSCHINI, Fulvio, GIUVA, Roberto, ZANINI, Alessandro
Format Patent
LanguageEnglish
French
German
Published 14.06.2023
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:A liposomal formulation with curcumin, where the amount of curcumin varies from 0.025% to 0.050% by weight of the total weight, is stable over time, even without preservatives and is sterilizable by filtration on 0.2 μm filter, so as to be usable as eye drops. Eye drops based on this liposomal formulation with curcumin additionally include the use of vitamin E-D-α-tocopherol polyethylene glycol (TPGS) with the dual purpose of promoting the formation and stability of liposomes and simultaneously providing a strong antioxidant effect. The vitamin E-TGPS is present in an amount between 0.025 and 0.5% by weight with respect to the final composition. A method for preparing these eye drops and the use thereof for the topical treatment of dry eye syndrome is described.
Bibliography:Application Number: EP20200771921