SYSTEMS AND PROCESSES FOR DISTINGUISHING SEQUENCES FROM MICROORGANISMS

• Main Authors: TRAN, David, AMINI, Sasan, MORTAZAVI, Sima, KRISHNAN, Prasanna Thwar, GEHRMANN, Henrik, TAYLOR, Michael, SHOKRALLA, Shadi, ALLRED, Adam Forrest, KHAKSAR, Ramin, BARNEY, Bryan Thomas, ZHANG, Shaokang, RHODEN, Kyle, LEE, Susan Jisoon
• Format: Patent
• Language: English; French; German
• Published: 25.05.2022
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; VINEGAR; WINE

Provided herein are fully-automated next-generation sequencing platforms and processes for detection of a target specimen (e.g., SARS-CoV-2) and for distinguishing infectious from non-infectious signals from the specimen. An analysis can provide simultaneous diagnosis and genomic surveillance of a multitude of distinct specimens in a sample information. The analysis can comprise distinguishing between infectious versus infectious specimens and provide a recommendation as to how infectious the sample can be. The information can be used to better inform the status of a subject or a location with regards to infectivity from the specimen.