NOVEL DRUG-CARRYING MICROSPHERE AND PREPARATION METHOD THEREFOR

• Main Authors: HUANG, Dan, WU, Jiexin, YANG, Yang, ZHANG, Yang, LI, Jing, LIU, Jingling, ZHANG, Chao, YANG, Yuexiong
• Format: Patent
• Language: English; French; German
• Published: 22.06.2022
• Subjects: AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; CHEMISTRY; COMPOSITIONS BASED THEREON; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; GENERAL PROCESSES OF COMPOUNDING; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METALLURGY; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; ORGANIC MACROMOLECULAR COMPOUNDS; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; THEIR PREPARATION OR CHEMICAL WORKING-UP; THEIR RELEVANT APPARATUS; TRANSPORTING; WORKING-UP

The present invention provides a novel microsphere capable of drug-loading and a preparation method thereof. The preparation method comprises pre-mixing an aqueous solution of polyvinyl alcohol and hydroxyapatite particles, then adding concentrated hydrochloric acid as a catalyst, and then adding the crosslinking agent glutaraldehyde to obtain the reaction liquid, after 3 seconds-30 seconds of pre-reaction, before the pre-reaction liquid is coagulated, the pre-reaction liquid is added dropwise to the mixture oil phase including liquid paraffin and sorbitan fatty acid ester, and the reaction is continued for at least 3 hours with stirring in an oil bath at 50°C-60°C, and then the reacted mixture is filtered, washed, and dried to obtain microspheres capable of drug-loading. The method of the present invention is conducive to mass production, and the microspheres capable of drug-loading prepared by the method have higher drug loading and encapsulation efficiency, with a good sustained release performance, and the hydroxyapatite particles are embedded in the poly(vinyl alcohol) after the polymerization reaction, makes the microspheres capable of drug-loading have a certain radiopaque function.