5-(THIOPHEN-2-YL)-1H-TETRAZOLE DERIVATIVES AS BCKDK INHIBITORS USEFUL FOR TREATING VARIOUS DISEASES

Described herein are compounds of Formula I,wherein R1, R2, and R3 are defined herein, their use as branched-chain alpha keto acid dehydrogenase kinase inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to treat, for example, diabetes, NASH and heart fa...

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Main Authors ZHANG, Yuan, FILIPSKI, Kevin James, ROTH FLACH, Rachel Jane, KORMOS, Bethany Lyn, REESE, Matthew Richard, BUTLER, Christopher Ryan, MARTINEZ-ALSINA, Luis Angel, BHATTACHARYA, Samit Kumar, OMOTO, Kiyoyuki, RAYMER, Brian, MILLER, Russell Alan
Format Patent
LanguageEnglish
French
German
Published 04.05.2022
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Described herein are compounds of Formula I,wherein R1, R2, and R3 are defined herein, their use as branched-chain alpha keto acid dehydrogenase kinase inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to treat, for example, diabetes, NASH and heart failure.
Bibliography:Application Number: EP20200743818