A FORMULATION OF A CONJUGATE OF A TUBULYSIN ANALOG TO A CELL-BINDING MOLECULE

A formulation of conjugates of tubulysin analogs with a cell-binding molecule having a structure represented by Formula (I), wherein T, L, m, n, ---, R1, R2, R3, R4, R1, R6, R7, R1, R9, R10, R11, R12, and R13 are as defined herein, can be used for targeted treatment of cancer, autoimmune disease, an...

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Main Authors LI, Wenjun, GUO, Zhixiang, DAI, Meng, HUANG, Yuanyuan, ZHAO, Robert, YANG, Qingliang, CHEN, Binbin, CHEN, Xiaoxiao, ZHAO, Linyao, YE, Hangbo, ZHANG, Lingli, ZHANG, Yu, ZHANG, Xiuzhen, GAI, Shun, LI, Yanhua, ZHENG, Jun, YANG, Yanlei, CHEN, Miaomiao, JIA, Junxiang, ZHOU, Lei, ZHOU, Xiaomai, GUO, Huihui, XU, Yifang, JIANG, Xingyan, ZHENG, Xiuhong, LIN, Chen, DU, Yong, KONG, Xiangfei, FAN, Zhongliang, BAI, Lu
Format Patent
LanguageEnglish
French
German
Published 15.11.2023
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:A formulation of conjugates of tubulysin analogs with a cell-binding molecule having a structure represented by Formula (I), wherein T, L, m, n, ---, R1, R2, R3, R4, R1, R6, R7, R1, R9, R10, R11, R12, and R13 are as defined herein, can be used for targeted treatment of cancer, autoimmune disease, and infectious disease.
Bibliography:Application Number: EP20200831886