SYSTEM AND METHOD FOR CHAFTACTERIZING CELLULAR PHENOTYPIC DIVERSITY FROM MULTI-PARAMETER CELLULAR. AND SUB-CELLULAR IMAGING DATA

A method of characterizing cellular phenotypes includes receiving multi-parameter cellular and sub-cellular imaging data for a number of tissue samples from a number of patients or a number of multicellular in vitro models, performing cellular segmentation on the multi-parameter cellular and sub-cel...

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Bibliographic Details
Main Authors PULLARA, Filippo, CHENNUBHOTLA, Srinivas C, FURMAN, Samantha A
Format Patent
LanguageEnglish
French
German
Published 08.02.2023
Subjects
CALCULATING
COMPUTING
COUNTING
PHYSICS
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Summary:A method of characterizing cellular phenotypes includes receiving multi-parameter cellular and sub-cellular imaging data for a number of tissue samples from a number of patients or a number of multicellular in vitro models, performing cellular segmentation on the multi-parameter cellular and sub-cellular imaging data to create segmented multi-parameter cellular and sub-cellular imaging data, and performing recursive decomposition on the segmented multi-parameter cellular and subcellular imaging data to identify a plurality of computational phenotypes. The recursive decomposition includes a plurality of levels of decomposition with each level of decomposition including soft/probabilistic clustering and spatial regularization, and each cell in the segmented multi-parameter cellular and subcellular imaging data is probabilistically assigned to one or more of the plurality of computational phenotypes.
Bibliography:Application Number: EP20200806243