SYSTEM AND METHOD FOR CHAFTACTERIZING CELLULAR PHENOTYPIC DIVERSITY FROM MULTI-PARAMETER CELLULAR. AND SUB-CELLULAR IMAGING DATA
A method of characterizing cellular phenotypes includes receiving multi-parameter cellular and sub-cellular imaging data for a number of tissue samples from a number of patients or a number of multicellular in vitro models, performing cellular segmentation on the multi-parameter cellular and sub-cel...
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Main Authors | , , |
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Format | Patent |
Language | English French German |
Published |
08.02.2023
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Subjects | |
Online Access | Get full text |
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Summary: | A method of characterizing cellular phenotypes includes receiving multi-parameter cellular and sub-cellular imaging data for a number of tissue samples from a number of patients or a number of multicellular in vitro models, performing cellular segmentation on the multi-parameter cellular and sub-cellular imaging data to create segmented multi-parameter cellular and sub-cellular imaging data, and performing recursive decomposition on the segmented multi-parameter cellular and subcellular imaging data to identify a plurality of computational phenotypes. The recursive decomposition includes a plurality of levels of decomposition with each level of decomposition including soft/probabilistic clustering and spatial regularization, and each cell in the segmented multi-parameter cellular and subcellular imaging data is probabilistically assigned to one or more of the plurality of computational phenotypes. |
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Bibliography: | Application Number: EP20200806243 |