CONVERGENT LIQUID PHASE SYNTHESES OF OLIGONUCLEOTIDES

The present disclosure describes a convergent liquid phase process for manufacturing oligonucleotides by coupling two or more oligonucleotide fragments, each of which have two or more nucleotides. Also provided by the present disclosure are reaction steps involved the convergent liquid phase process...

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Bibliographic Details
Main Authors FILLON, Yannick, SHI, Xianglin, NGUYEN, Hien, ICHIMARU, Taisuke, YAN, Wuming, GRONKE, Robert, S, TAKAHASHI, Daisuke, JIANG, Hong, HAMAGAKI, Takuya, KIESMAN, William, F, ANTIA, Firoz, ZHOU, Xuan
Format Patent
LanguageEnglish
French
German
Published 16.03.2022
Subjects
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Summary:The present disclosure describes a convergent liquid phase process for manufacturing oligonucleotides by coupling two or more oligonucleotide fragments, each of which have two or more nucleotides. Also provided by the present disclosure are reaction steps involved the convergent liquid phase process.
Bibliography:Application Number: EP20200729413