COMPOSITIONS, DEVICES AND METHODS FOR FACTOR VII THERAPY

Described herein are RPE cells engineered to secrete a FVII protein, as well as compositions, pharmaceutical preparations, and implantable devices comprising the engineered RPE cells, and methods of making and using the same for treating a patient with hemophilia or FVII deficiency.

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Bibliographic Details
Main Authors CARMONA, Guillaume, JOHNSTON, Erika Ellen, WOTTON, Paul Kevin, OBERLI, Matthias Alexander, YIN, Zoe, HEIDEBRECHT, Richard, VEISEH, Omid, O'CONNOR, Owen, SEWELL, Jared A, BEAUREGARD, Michael, MILLER, Robert James, PERITT, David, SMITH, Devyn McKinley, BARNEY, Lauren Emily, GONZALEZ, Francisco Caballero
Format Patent
LanguageEnglish
French
German
Published 12.07.2023
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Described herein are RPE cells engineered to secrete a FVII protein, as well as compositions, pharmaceutical preparations, and implantable devices comprising the engineered RPE cells, and methods of making and using the same for treating a patient with hemophilia or FVII deficiency.
Bibliography:Application Number: EP20200778410