PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF

Provided herein are compounds, compositions, and methods useful for inhibiting protein tyrosine phosphatase, e.g., protein tyrosine phosphatase non-receptor type 2 (PTPN2) and/or protein tyrosine phosphatase non-receptor type 1 (PTPN1), and for treating related diseases, disorders and conditions fav...

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Main Authors FOSU, Stacy, XIONG, Zhaoming, KYM, Philip R, FARNEY, Elliot P, O'CONNOR, Matthew, ECONOMOU, Christos, HALVORSEN, Geoff T, MATULENKO, Mark A, VOIGHT, Eric, BOGDAN, Andrew, ABBOTT, Jason, SHIROODI, Reza, ZHANG, Qingwei I, FROST, Jennifer M, BAUMGARTNER, Christina
Format Patent
LanguageEnglish
French
German
Published 19.01.2022
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Provided herein are compounds, compositions, and methods useful for inhibiting protein tyrosine phosphatase, e.g., protein tyrosine phosphatase non-receptor type 2 (PTPN2) and/or protein tyrosine phosphatase non-receptor type 1 (PTPN1), and for treating related diseases, disorders and conditions favorably responsive to PTPN1 or PTPN2 inhibitor treatment, e.g., a cancer or a metabolic disease.
Bibliography:Application Number: EP20200717505