CHITOSAN POLYPLEX-BASED LOCALIZED EXPRESSION OF IL-12 ALONE OR IN COMBINATION WITH TYPE-I IFN INDUCERS FOR TREATMENT OF MUCOSAL CANCERS

Chitosan-nucleic acid polyplex compositions containing a reversibly bound polymer coat comprising linear block copolymers with a polyanionic anchor region and at least one polyethylene glycol tail region are described herein. In some cases, the compositions exhibit improved stability and/or mucosal...

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Bibliographic Details
Main Authors PANICKER, Rajesh, Krishnan Gopalakrishna, TAM, Natalie, Chin Mun, MA, Pei, Lian, CHEUNG, Anthony, FLEET, Carlos, VEILLEUX, Daniel, LORA, Jose, DAUPHINEE, Shauna, CHEN, Ximin
Format Patent
LanguageEnglish
French
German
Published 21.02.2024
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
DERIVATIVES THEREOF
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
SUGARS
VINEGAR
WINE
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Summary:Chitosan-nucleic acid polyplex compositions containing a reversibly bound polymer coat comprising linear block copolymers with a polyanionic anchor region and at least one polyethylene glycol tail region are described herein. In some cases, the compositions exhibit improved stability and/or mucosal diffusion as compared to uncoated particles. In some cases, the reversibly bound polymer coat does not interfere with, or enhances, transfection of target cells or tissues as compared to uncoated particles.
Bibliography:Application Number: EP20200770620