TIME MULTIPLEXED WAVEFORM FOR SELECTIVE CELL ABLATION

• Main Authors: CAO, Hong, FORSYTH, Bruce R, CANADY, Larry D. Jr, GORZYCKI, Jonathan Tyler, OSTROOT, Timothy A
• Format: Patent
• Language: English; French; German
• Published: 19.01.2022
• Subjects: DIAGNOSIS; ELECTROTHERAPY; HUMAN NECESSITIES; HYGIENE; IDENTIFICATION; MAGNETOTHERAPY; MEDICAL OR VETERINARY SCIENCE; RADIATION THERAPY; SURGERY; ULTRASOUND THERAPY

The present invention discloses a pulse generator configured for use with a probe for delivering ablation therapy to a patient, the pulse generator comprising output circuitry for delivering voltage-based therapy, monitoring circuitry for monitoring characteristics of delivered therapy pulses, and control circuitry comprising a non-volatile memory containing an executable instruction set adapted to deliver therapy, characterized in that the therapy comprises: a first pulse of a first polarity having a first amplitude and a first pulse width; a first pulse train having a plurality of second pulses of a second polarity opposite the first polarity, the second pulses having second amplitudes and second pulse widths, the second pulse widths being less than one-half of the first pulse width; such that the first pulse yields a first charge imbalance, and the first pulse train yields a second charge imbalance that offsets the first charge imbalance to prevent muscle stimulation.