ALPHA-CINNAMIDE COMPOUNDS AND COMPOSITIONS AS HDAC8 INHIBITORS

The present invention relates to inhibitors of histone deacetylases, in particular HDAC8, that are useful for the treatment of cancer and other diseases and disorders, as well as the synthesis and applications of said inhibitors.

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Bibliographic Details
Main Authors THOMASON, Jennifer R, LIU, Cuixian, ZABLOCKI, Mary-Margaret, MARTIN, Matthew W, BARCZAK, Nicholas, HAN, Bingsong, BAIR, Kenneth W, NG, Pui Yee, RUDNITSKAYA, Aleksandra, LANCIA, David R., Jr, ZHENG, Xiaozhang
Format Patent
LanguageEnglish
French
German
Published 05.01.2022
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to inhibitors of histone deacetylases, in particular HDAC8, that are useful for the treatment of cancer and other diseases and disorders, as well as the synthesis and applications of said inhibitors.
Bibliography:Application Number: EP20210169630