5'-MODIFIED NUCLEOSIDE AND NUCLEOTIDE USING SAME

Disclosed are a 5'-modified nucleoside and a nucleotide using the same. The nucleoside of the present invention is represented by the formula (I) below. The 5'-modified nucleoside of the present invention is usable as a substitute for a phosphorothioate-modified nucleic acid, which has a r...

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Bibliographic Details
Main Authors OBIKA, Satoshi, YAMAGUCHI, Takao, YOSHIDA, Tokuyuki, KATO, Go, HABUCHI, Takaki, INOUE, Takao, ISLAM, Md Ariful
Format Patent
LanguageEnglish
French
German
Published 27.04.2022
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
DERIVATIVES THEREOF
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
SUGARS
VINEGAR
WINE
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Summary:Disclosed are a 5'-modified nucleoside and a nucleotide using the same. The nucleoside of the present invention is represented by the formula (I) below. The 5'-modified nucleoside of the present invention is usable as a substitute for a phosphorothioate-modified nucleic acid, which has a risk of, for example, accumulation in a specific organ. The 5'-modified nucleoside also has excellent industrial productivity because a diastereomer separation step is not involved in the production process thereof.
Bibliography:Application Number: EP20200756660