COMPUTATIONAL SYSTEMS PATHOLOGY SPATIAL ANALYSIS PLATFORM FOR IN SITU OR IN VITRO MULTI-PARAMETER CELLULAR AND SUBCELLULAR IMAGING DATA
A computational systems pathology spatial analysis platform includes: (i) a spatial heterogeneity quantification component configured for generating a global quantification of spatial heterogeneity among cells of varying phenotypes in multi-parameter cellular and subcellular imaging data; (ii) a mic...
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Main Authors | , , |
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Format | Patent |
Language | English French German |
Published |
16.03.2022
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Subjects | |
Online Access | Get full text |
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Summary: | A computational systems pathology spatial analysis platform includes: (i) a spatial heterogeneity quantification component configured for generating a global quantification of spatial heterogeneity among cells of varying phenotypes in multi-parameter cellular and subcellular imaging data; (ii) a microdomain identification component configured for identifying a plurality of microdomains for tissue samples based on the global quantification, each microdomain being associated with a tissue sample; and (iii) a weighted graph component configured for constructing a weighted graph for the multi-parameter cellular and subcellular imaging data, the weighted graph having a plurality of nodes and a plurality of edges each being located between a pair of the nodes, wherein in the weighted graph each node is a particular one of the microdomains and the edge between each pair of microdomains in the weighted graph is indicative of a degree of similarity between the pair of the microdomains. |
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Bibliography: | Application Number: EP20190898372 |