SYSTEMS AND METHODS FOR HIGH THROUGHPUT COMPOUND LIBRARY CREATION

• Main Authors: QUIGLEY, Ian, HEALEY, David, VICTORS, Mason, L, ALFA, Ronald, Wakim, GIBSON, Chris, BORGESON, Blake, C
• Format: Patent
• Language: English; French; German
• Published: 24.08.2022
• Subjects: CHEMISTRY; COMBINATORIAL CHEMISTRY; INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES; METALLURGY; PHYSICS

The disclosure provides methods and systems for identifying a subset of compounds in a plurality of compounds. The identifying includes obtaining, for each compound, a vector including a set of elements, where each element includes a measurement of a different feature of an instance of a cell context upon exposure to the compound. The identifying includes performing the obtaining for a plurality of cell contexts, to obtain a plurality of vectors for each compound across different cell contexts. The identifying includes combining the vectors for each compound to form a combined vector for each compound, thereby forming a plurality of combined vectors representing different compounds. The identifying includes pruning the plurality of compounds to the subset of compounds based on a similarity between respective combined vectors in the plurality of combined vectors corresponding to compounds in the plurality of compounds.