MULTISPECIFIC MUTATED ANTIBODY FAB FRAGMENTS

The invention relates to multispecific antibody constructs comprising Fab fragments having mutations at the interface of the CH1 and CL domains, said mutations preventing heavy chain/light chain mispairing.

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Bibliographic Details
Main Authors MICHIELIN, Olivier, IWASZKIEWICZ, Justyna, KADOUCHE, Jean, ZOETE, Vincent, GOLAY, Josée, MACH, Jean-Pierre, CERUTTI, Martine, CHOBLET, Sylvie
Format Patent
LanguageEnglish
French
German
Published 01.09.2021
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The invention relates to multispecific antibody constructs comprising Fab fragments having mutations at the interface of the CH1 and CL domains, said mutations preventing heavy chain/light chain mispairing.
Bibliography:Application Number: EP20200168633