ACTIVATING PYRUVATE KINASE R

The disclosure provides novel chemical compounds useful as activators of PKR. PKR activating compounds are useful in the treatment of disease and disorders associated with modulation of PKR and/or PKM2, such as pyruvate kinase deficiency (PKD).

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Bibliographic Details
Main Authors SHELEKHIN, Tatiana, LIN, Jian, LANCIA, David, R. Jr, GREEN, Neal, ERICSSON, Anna, MITCHELL, Lorna, GUSTAFSON, Gary, RICHARD, David, ZHENG, Xiaozhang
Format Patent
LanguageEnglish
French
German
Published 03.07.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The disclosure provides novel chemical compounds useful as activators of PKR. PKR activating compounds are useful in the treatment of disease and disorders associated with modulation of PKR and/or PKM2, such as pyruvate kinase deficiency (PKD).
Bibliography:Application Number: EP20190862479