PRE-FILLED SYRINGE AND PRE-FILLED SYRINGE PRODUCTION METHOD

• Main Author: SAWAGUCHI, Taichi
• Format: Patent
• Language: English; French; German
• Published: 29.12.2021
• Subjects: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

Provided is a pre-filled syringe that can inhibit protein aggregation after long-term storage even when filled with a protein solution formulation having a low non-ionic surfactant concentration. The pre-filled syringe includes: a barrel formed of a resin containing a hydrogenated cycloolefin ring-opened polymer and/or a copolymer of a cycloolefin and a chain olefin; a sealing member sealing a nozzle of the barrel; a gasket housed inside the barrel; and a plunger performing a movement operation of the gasket, and contains a protein solution formulation in a space defined by the sealing member, the gasket, and a region that is part of an inner wall surface of the barrel. The region that is part of the inner wall surface has a water contact angle of 90° or more. The protein solution formulation has a non-ionic surfactant concentration of 0 mg/mL to 0.01 mg/mL.