PROCESS FOR THE PREPARATION OF BROMODOMAIN INHIBITOR

The present invention provides processes of synthesis and purification of a bromodomain inhibitor, Compound 1, which compound includes crystalline forms, amorphous forms, solvates, and hydrates thereof. Embodiments of the disclosure relate to chemical synthesis routes of Compound 1 that provide a sc...

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Bibliographic Details
Main Authors ALITE, Hekla, MOSELEY, Jonathan, FERRETTI, Antonio Christian, TRAVERSE, John Fitzgerald, YONG, Kelvin Hin-Yeong, PRIMER, David, RUDA, Antonio Maria, PHILP, Steven
Format Patent
LanguageEnglish
French
German
Published 02.06.2021
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention provides processes of synthesis and purification of a bromodomain inhibitor, Compound 1, which compound includes crystalline forms, amorphous forms, solvates, and hydrates thereof. Embodiments of the disclosure relate to chemical synthesis routes of Compound 1 that provide a scalable method that results in highly pure final product. A further embodiment relates to methods to isolate the most stable polymorph of Compound 1 by crystallization from formic acid and water.
Bibliography:Application Number: EP20190794724