PHENYL AND PYRIDINYL SUBSTITUTED IMIDAZOLES AS MODULATORS OF RORYT

The present invention comprises compounds of Formula I.wherein:R1, R2, R3, R4, R5, Ra, Rb, Q1, and Q2 are defined in the specification.The invention also comprises a method of treating or ameliorating a ROR-γ-t mediated syndrome, disorder or disease, including wherein the syndrome, disorder or disea...

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Main Authors MARTIN, Connor L, KUMMER, David A, GOLDBERG, Steven, FOURIE, Anne M, FENNEMA, Elizabeth G, NISHIMURA, Rachel T, TANIS, Virginia M, WOODS, Craig R, XUE, Xiaohua
Format Patent
LanguageEnglish
French
German
Published 21.04.2021
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention comprises compounds of Formula I.wherein:R1, R2, R3, R4, R5, Ra, Rb, Q1, and Q2 are defined in the specification.The invention also comprises a method of treating or ameliorating a ROR-γ-t mediated syndrome, disorder or disease, including wherein the syndrome, disorder or disease is selected from the group consisting of rheumatoid arthritis, psoriatic arthritis, and psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula I.
Bibliography:Application Number: EP20190758804