IRE-1A INHIBITORS

Compounds which directly inhibit IRE-1α activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof. Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response or with regulated IRE1-dependent decay (RIDD) and can be used as single agent...

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Bibliographic Details
Main Authors WADE, Warren Stanfield, ZENG, Qingping, PATTERSON, John, Bruce, ZUBOVICS, Zoltan, YANG, Yun, WU, Zhipeng, TORO, Andras
Format Patent
LanguageEnglish
French
German
Published 07.04.2021
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Compounds which directly inhibit IRE-1α activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof. Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response or with regulated IRE1-dependent decay (RIDD) and can be used as single agents or in combination therapies.
Bibliography:Application Number: EP20200209114