MELOXICAM COMPOSITION, PREPARATION AND PREPARATION METHOD AND USE THEREOF

The invention provides a meloxicam compositions, pharmaceutical preparations, preparation methods and use thereof. In one aspect of the invention, meloxicam compositions containing meloxicam and cosolvents are provided, wherein the cosolvents are mixed solvents including water and organic solvents....

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Bibliographic Details
Main Authors ZHOU, Wenliang, WU, Qu, ZOU, Limin, WANG, Qingsong
Format Patent
LanguageEnglish
French
German
Published 07.07.2021
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention provides a meloxicam compositions, pharmaceutical preparations, preparation methods and use thereof. In one aspect of the invention, meloxicam compositions containing meloxicam and cosolvents are provided, wherein the cosolvents are mixed solvents including water and organic solvents. In another aspect of the invention, other compositions comprising meloxicam, solvents, and pH regulators are provided, wherein the pH regulators include at least citric acid. The pharmaceutical compositions of the invention can significantly enhance the solubility of meloxicam in liquid pharmaceutical preparations, as well as excellent stability. The meloxicam compositions provided in the invention can even be directly used for intravenous injection administration to quickly reach effective therapeutic concentrations for post-operative analgesia. Furthermore, the preparation technique of the compositions is convenient that it can be completed by stirring and dispersing in a short time at room temperature, and the large-scale production is easy to be achieved.
Bibliography:Application Number: EP20190800759