RECOMBINANT ALKALINE PHOSPHATASE FOR USE IN TREATING SEPSIS-ASSOCIATED ACUTE KIDNEY INJURY

The present disclosure relates to the use of alkaline phosphatases, and in particular improved alkaline phosphatases such as RecAP, for the prevention, treatment, cure, or amelioration of the symptoms of acute kidney injury caused, e.g., by sepsis. The application relates to methods of preserving re...

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Bibliographic Details
Main Authors MURRAY, Patrick Thomas, JOANNIDIS, Michael, MEHTA, Ravindra Lall, AREND, Jacques Salomon Robert, VAN DEN BERG, Erik Jan, PICKKERS, Roelof Peter
Format Patent
LanguageEnglish
French
German
Published 13.01.2021
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present disclosure relates to the use of alkaline phosphatases, and in particular improved alkaline phosphatases such as RecAP, for the prevention, treatment, cure, or amelioration of the symptoms of acute kidney injury caused, e.g., by sepsis. The application relates to methods of preserving renal function, shortening the duration of renal replacement therapy, increasing the creatinine clearance, decreasing the risk of death in subjects with sepsis-associate acute kidney injury (SA-AKI) or at risk of SA-AKI.
Bibliography:Application Number: EP20190721159