2,3,4,5-TETRAHYDRO-1H-PYRIDO[4, 3-B]INDOLE INHIBITORS OF CGAS FOR TREATING AUTOINFLAMMATORY DISEASES

1-(3,4-Dihydro-1H-pyrido[4, 3-b]indol-2(5H)-yl)-2-hydroxyethanonesare disclosed. The compounds are inhibitors of human cGAS in interferon-producing cell types. They are thus useful as therapeutic agents for treating cGAS-related autoimmune diseases in humans.

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Bibliographic Details
Main Authors OKAMOTO, Rei, PATEL, Dinshaw, LAMA, Lodoe, KAMEI, Taku, AIDA, Jumpei, TUSCHL, Thomas, GLICKMAN, J. Fraser, ASANO, Yasutomi, IMAEDA, Toshihiro, MILLER, Michael, HASHIZUME, Shogo, KUROITA, Takanobu, TOMITA, Daisuke, MICHINO, Mayako
Format Patent
LanguageEnglish
French
German
Published 16.12.2020
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:1-(3,4-Dihydro-1H-pyrido[4, 3-b]indol-2(5H)-yl)-2-hydroxyethanonesare disclosed. The compounds are inhibitors of human cGAS in interferon-producing cell types. They are thus useful as therapeutic agents for treating cGAS-related autoimmune diseases in humans.
Bibliography:Application Number: EP20190746977