L2A5 ANTIBODY OR FUNCTIONAL FRAGMENT THEREOF AGAINST TUMOUR ANTIGENS

This invention provides an antibody or functional antibody fragments, or probe thereof directed against a unique group of antigens identified in cancer.The present invention comprises nucleotide sequences derived from L2A5 monoclonal antibody. The antibody or functional antibody fragment, or probe t...

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Main Authors CARRASCAL, Mylène Adelaide do Rosário, PALMA, María Angelina de Sá, SANTOS, Lúcio Lara, NOVO, Carlos Manuel Mendes, LOUREIRO, Liliana Raquel Rodrigues, FERREÍRA, José Alexandre Ribeiro de Castro, LIMA, Luís Carlos Oliveira, VIDEIRA, Paula Alexandra Quintela, BACHMANN, Michael, CHAI, Wengang
Format Patent
LanguageEnglish
French
German
Published 12.06.2024
Subjects
CHEMISTRY
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
TESTING
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Summary:This invention provides an antibody or functional antibody fragments, or probe thereof directed against a unique group of antigens identified in cancer.The present invention comprises nucleotide sequences derived from L2A5 monoclonal antibody. The antibody or functional antibody fragment, or probe thereof includes a variable heavy chain domain and a variable light chain domain that has an amino acid sequence provided herein. This DNA/amino acid sequence conjugation is unique and has never been described before. The present invention further provides antibody or functional antibody fragment or a conjugate or a recombinant protein useful in the detection, treatment and prevention of human disease, including cancer.
Bibliography:Application Number: EP20190702492