DEGRADABLE VASCULAR STENT CAPABLE OF AVOIDING LATE RESTENOSIS

• Main Authors: MU, Yunhong, HUANG, Bin, WEI, Zheng, XIE, Jian
• Format: Patent
• Language: English; French; German
• Published: 16.08.2023
• Subjects: BANDAGES, DRESSINGS OR ABSORBENT PADS; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; FILTERS IMPLANTABLE INTO BLOOD VESSELS; FIRST-AID KITS; FOMENTATION; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; PROSTHESES; TREATMENT OR PROTECTION OF EYES OR EARS

The present invention relates to a degradable vascular stent capable of avoiding late restenosis, comprising a base region (111a, 111b, 111c, 111d, 111e, 111f, 111g, 111h, 111i) formed by a polylactic acid based polymer; at least one storage region (112a, 112b, 112c, 112d, 112e, 112f, 112g, 112h, 112i) in which an active agent is stored; and an outer layer of a drug sustained release coating (12a, 12b, 12c, 12d, 12e, 12f, 12g, 12h, 12i) covered on the base region (111a, 111b, 111c, 111d, 111e, 111f, 111g, 111h, 111i) and/or the storage region (112a, 112b, 112c, 112d, 112e, 112f, 112g, 112h, 112i). Before the mass of the polylactic acid based polymer of the base region (111a, 111b, 111c, 111d, 111e, 111f, 111g, 111h, 111i) is decreased by 10-20%, the active agent in the storage region (112a, 112b, 112c, 112d, 112e, 112f, 112g, 112h, 112i) is retained in structural units of the polylactic acid based polymer. After the mass of the polylactic acid based polymer of the base region (111a, 111b, 111c, 111d, 111e, 111f, 111g, 111h, 111i) is decreased by 10-20%, the active agent in the storage region (112a, 112b, 112c, 112d, 112e, 112f, 112g, 112h, 112i) is released from the storage region (112a, 112b, 112c, 112d, 112e, 112f, 112g, 112h, 112i). According to the degradable vascular stent capable of avoiding late restenosis, the base region (111a, 111b, 111c, 111d, 111e, 111f, 111g, 111h, 111i) serves as a main body to mainly provide a supporting capacity for ensuring the patency of blood vessels; the drug sustained release coating (12a, 12b, 12c, 12d, 12e, 12f, 12g, 12h, 12i) covered on the base region is used for drug release in an early stage after implantation; and the active agent stored in storage region (112a, 112b, 112c, 112d, 112e, 112f, 112g, 112h, 112i) only works in late degradation of the stent to avoid late restenosis.