COMPOUNDS FOR TREATING AND PREVENTING EXTRACELLULAR HISTONE MEDIATED PATHOLOGIES

• Main Authors: O'MEARA, Connor, BROWNE, Anna, KNOX, Karen, PHILIP, Lee Andrew, VON ITZSTEIN, Laurence Mark, BEZOS, Anna, CHANG, Chih-Wei, DAVIS, David Anak Simon, PARISH, Christopher, KORDBACHEH, Farzaneh, STEPHENS, Ross, COUPLAND, Lucy, QUAH, Benjamin Ju Chye, BRÜSTLE, Anne, TREDWELL, Gregory David
• Format: Patent
• Language: English; French; German
• Published: 21.10.2020
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to compounds with high chemical stability and methods for inhibiting the pathological activity of extracellular histones in a subject. In particular, the invention relates to compounds with high chemical stability, uses thereof and methods for inhibiting or ameliorating extracellular histone mediated ailments (such as, for example, sepsis, systemic immune response syndrome (SIRS) and ischemia reperfusion injury (IRO). More particularly, the invention relates to methods and uses of a polyanionic sulfated cellobioside modified with a small uncharged glycosidically linked substituent at its reducing terminus, wherein the presence of the substituent results in a molecule with high chemical stability without affecting the ability of the molecule to be effective in the therapy of extracellular histone mediated ailments. For example, the present invention relates to methods and uses of β-O-methyl cellobioside sulfate (mCBS) or a pharmaceutically acceptable salt thereof (e.g., mCBS·Na), in the therapy of a range of extracellular histone mediated ailments in subjects.