3'END CAPS FOR RNA-INTERFERRING AGENTS FOR USE IN RNA

The disclosure relates to novel compounds and compositions comprising a RNAi agent comprising a novel compound as a 3' end cap. The disclosure also relates to processes for making such compositions, and methods and uses of such compositions, e.g., to mediate RNA interference.

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Main Authors ZHU, Meicheng, BLOMMERS, Marcel, GREENIDGE, Paulette, HUNZIKER, Juerg, WEILER, Jan, HUESKEN, Dieter, FERNANDEZ, Cesar, PATNAIK, Anup, PATTERSON, Andrew, GOSSERT, Alvar, NATT, Francois Jean-Charles, GENO, Erin, BARYZA, Jeremy Lee, RONDEAU, Jean-Michel Rene
Format Patent
LanguageEnglish
French
German
Published 14.10.2020
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Abstract The disclosure relates to novel compounds and compositions comprising a RNAi agent comprising a novel compound as a 3' end cap. The disclosure also relates to processes for making such compositions, and methods and uses of such compositions, e.g., to mediate RNA interference.
AbstractList The disclosure relates to novel compounds and compositions comprising a RNAi agent comprising a novel compound as a 3' end cap. The disclosure also relates to processes for making such compositions, and methods and uses of such compositions, e.g., to mediate RNA interference.
Author ZHU, Meicheng
HUESKEN, Dieter
FERNANDEZ, Cesar
PATNAIK, Anup
GREENIDGE, Paulette
HUNZIKER, Juerg
BARYZA, Jeremy Lee
BLOMMERS, Marcel
RONDEAU, Jean-Michel Rene
NATT, Francois Jean-Charles
GENO, Erin
GOSSERT, Alvar
PATTERSON, Andrew
WEILER, Jan
Author_xml – fullname: ZHU, Meicheng
– fullname: BLOMMERS, Marcel
– fullname: GREENIDGE, Paulette
– fullname: HUNZIKER, Juerg
– fullname: WEILER, Jan
– fullname: HUESKEN, Dieter
– fullname: FERNANDEZ, Cesar
– fullname: PATNAIK, Anup
– fullname: PATTERSON, Andrew
– fullname: GOSSERT, Alvar
– fullname: NATT, Francois Jean-Charles
– fullname: GENO, Erin
– fullname: BARYZA, Jeremy Lee
– fullname: RONDEAU, Jean-Michel Rene
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Sciences
DocumentTitleAlternate 3 EMBOUTS POUR DES AGENTS ARNI UTILISÉS DANS L'ARN
3'-ENDKAPPEN FÜR RNA-INTERFERENZ-WIRKSTOFFE ZUR VERWENDUNG IN RNA
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RelatedCompanies Novartis AG
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Snippet The disclosure relates to novel compounds and compositions comprising a RNAi agent comprising a novel compound as a 3' end cap. The disclosure also relates to...
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SourceType Open Access Repository
SubjectTerms ACYCLIC OR CARBOCYCLIC COMPOUNDS
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HETEROCYCLIC COMPOUNDS
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
Title 3'END CAPS FOR RNA-INTERFERRING AGENTS FOR USE IN RNA
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