PRODRUGS OF SUBSTITUTED TRIAZOLE DERIVATIVES AND USES THEREOF

• Main Authors: KRENZ, Ursula, NEUBAUER, Thomas, FRICKE, Robert, TINEL, Hanna, KOLKHOF, Peter, WITTWER, Matthias, Beat, BUCHMUELLER, Anja, WASNAIRE, Pierre, KRETSCHMER, Axel, CERNECKA, Hana, SCHMECK, Carsten, LUSTIG, Klemens, FUERSTNER, Chantal, LEVILAIN, Guillaume, POOK, Elisabeth, MONDRITZKI, Thomas, WITOWSKI, Norbert, DROEBNER, Karoline, COLLIN-KROEPELIN, Marie-Pierre, SCHIRMER, Heiko
• Format: Patent
• Language: English; French; German
• Published: 10.11.2021
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to prodrugs of 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl ]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-[3-(trifluoromethyl)-pyridin-2-yl ]-1H-1,2,4-triazole-5-carboxamide, 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl ]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-[2-(trifluoromethyl)-phenyl]-1H-1,2,4-triazole-5-carboxamide and 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl ]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-(3-chloropyridin-2-yl)-1H-1,2,4-triazole-5-carboxamide, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.