SYNTHESIS OF ICATIBANT

The present invention relates to the efficient solid-phase synthesis of Icatibant represented by Formula (I). The present invention relates to an efficient process for the preparation of Icatibant by sequential coupling employing solid phase approach. It involves sequential coupling of protected ami...

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Bibliographic Details
Main Authors RAMU, Vasanthakumar, Ganga, YOGESHA, PALLE, Venkata, Raghavendracharyulu, PATIL, Nitin, Sopanrao
Format Patent
LanguageEnglish
French
German
Published 05.08.2020
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:The present invention relates to the efficient solid-phase synthesis of Icatibant represented by Formula (I). The present invention relates to an efficient process for the preparation of Icatibant by sequential coupling employing solid phase approach. It involves sequential coupling of protected amino acids to prepare Icatibant. The present invention also involves the usage of inorganic salts during the coupling, wash with HOBt in DMF solution after Fmoc-deprotection step to ensure complete removal of piperidine and reactions are going for completion, and thus avoid addition/deletion sequences and also improve the process yield.
Bibliography:Application Number: EP20180861354