PYRUVATE KINASE ACTIVATORS FOR USE IN TREATING BLOOD DISORDERS

Described herein are compounds that activate pyruvate kinase, pharmaceutical compositions and methods of use thereof. These compounds are represented by Formula (I):wherein R1, R2, Ra, Rb, Rj, Rk, and Q are as defined herein.

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Bibliographic Details
Main Authors CUI, Dawei, LIU, Tao, JI, Jingjing, CIANCHETTA, Giovanni, SUI, Zhihua, PADYANA, Anil, Kumar, CAI, Zhenwei
Format Patent
LanguageEnglish
French
German
Published 24.06.2020
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Described herein are compounds that activate pyruvate kinase, pharmaceutical compositions and methods of use thereof. These compounds are represented by Formula (I):wherein R1, R2, Ra, Rb, Rj, Rk, and Q are as defined herein.
Bibliography:Application Number: EP20180779068