MACROCYCLIC MCL-1 INHIBITORS AND METHODS OF USE

The present disclosure provides for compounds of Formula (I)wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatmen...

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Main Authors DAI, Yujia, KLING, Andreas, DOHERTY, George, LAI, Chunqiu, POHLKI, Frauke, SULLIVAN, Gerard, SOUERS, Andrew, TESKE, Jesse, JI, Cheng, JANTOS, Katja, YU, Yiyun, ZHU, Guidong, PENNING, Thomas, JUDD, Andrew, KUNZER, Aaron, RISI, Roberto, WENDT, Michael, BRAJE, Wilfried, TAO, Zhi-Fu, GUILLIER, Fabrice, BRADY, Patrick, WANG, Xilu, GONG, Jane, MASTRACCHIO, Anthony, SONG, Xiaohong, POTIN, Dominique
Format Patent
LanguageEnglish
French
German
Published 05.05.2021
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Abstract The present disclosure provides for compounds of Formula (I)wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).
AbstractList The present disclosure provides for compounds of Formula (I)wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).
Author YU, Yiyun
DOHERTY, George
DAI, Yujia
MASTRACCHIO, Anthony
SULLIVAN, Gerard
POHLKI, Frauke
GONG, Jane
JUDD, Andrew
TAO, Zhi-Fu
TESKE, Jesse
LAI, Chunqiu
KLING, Andreas
GUILLIER, Fabrice
WANG, Xilu
JANTOS, Katja
WENDT, Michael
BRADY, Patrick
JI, Cheng
ZHU, Guidong
RISI, Roberto
SONG, Xiaohong
PENNING, Thomas
KUNZER, Aaron
BRAJE, Wilfried
SOUERS, Andrew
POTIN, Dominique
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– fullname: KLING, Andreas
– fullname: DOHERTY, George
– fullname: LAI, Chunqiu
– fullname: POHLKI, Frauke
– fullname: SULLIVAN, Gerard
– fullname: SOUERS, Andrew
– fullname: TESKE, Jesse
– fullname: JI, Cheng
– fullname: JANTOS, Katja
– fullname: YU, Yiyun
– fullname: ZHU, Guidong
– fullname: PENNING, Thomas
– fullname: JUDD, Andrew
– fullname: KUNZER, Aaron
– fullname: RISI, Roberto
– fullname: WENDT, Michael
– fullname: BRAJE, Wilfried
– fullname: TAO, Zhi-Fu
– fullname: GUILLIER, Fabrice
– fullname: BRADY, Patrick
– fullname: WANG, Xilu
– fullname: GONG, Jane
– fullname: MASTRACCHIO, Anthony
– fullname: SONG, Xiaohong
– fullname: POTIN, Dominique
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DocumentTitleAlternate INHIBITEURS DE MCL-1 MACROCYCLIQUE ET PROCÉDÉS D'UTILISATION
MAKROCYCLISCHE MCL-1-INHIBITOREN UND VERWENDUNGSVERFAHREN
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Snippet The present disclosure provides for compounds of Formula (I)wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y...
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SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title MACROCYCLIC MCL-1 INHIBITORS AND METHODS OF USE
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