MACROCYCLIC MCL-1 INHIBITORS AND METHODS OF USE

The present disclosure provides for compounds of Formula (I)wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatmen...

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Main Authors DAI, Yujia, KLING, Andreas, DOHERTY, George, LAI, Chunqiu, POHLKI, Frauke, SULLIVAN, Gerard, SOUERS, Andrew, TESKE, Jesse, JI, Cheng, JANTOS, Katja, YU, Yiyun, ZHU, Guidong, PENNING, Thomas, JUDD, Andrew, KUNZER, Aaron, RISI, Roberto, WENDT, Michael, BRAJE, Wilfried, TAO, Zhi-Fu, GUILLIER, Fabrice, BRADY, Patrick, WANG, Xilu, GONG, Jane, MASTRACCHIO, Anthony, SONG, Xiaohong, POTIN, Dominique
Format Patent
LanguageEnglish
French
German
Published 05.05.2021
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present disclosure provides for compounds of Formula (I)wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).
Bibliography:Application Number: EP20180846740