NOVEL HETEROCYCLIC COMPOUNDS AS CDK8/19 INHIBITORS

• Main Authors: KASATKINA, Mariia Andreevna, CHESTNOVA, Anna Jur'evna, GORBUNOVA, Svetlana Leonidovna, ZAVIALOV, Kirill Vadimovich, KOZHEMYAKINA, Natalia Vladimirovna, POPKOVA, Aleksandra Vladimirovna, ALAFINOV, Andrei Ivanovich, IAKOVLEV, Pavel Andreevich, KUSHAKOVA, Anna Sergeevna, MOROZOV, Dmitry Valentinovich, MINDICH, Aleksei Leonidovich, SHEKHAUTSOU, Artsiom Evgenievich, ALESHUNIN, Pavel Aleksandrovich, REKHARSKY, Mikhail Vladimirovich, EVDOKIMOV, Anton Aleksandrovich, MAKSIMENKO, Elena Aleksandrovna, MISHINA, Mariia Sergeevna
• Format: Patent
• Language: English; French; German
• Published: 17.06.2020
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to novel compounds of formula (I):or a pharmaceutically acceptable salt or stereoisomer thereof, which exhibit the properties of a CDK 8/19 inhibitor. The invention also relates to a pharmaceutical composition containing said compounds and to the use thereof as pharmace...