METHODS AND COMPOSITIONS FOR HETEROLOGOUS REPRNA IMMUNIZATIONS

Compositions and methods are described for inducing an immune response against an immunogen in humans. The induced immune response is obtained by administering a heterologous prime-boost combination of an in vitro transcribed (IVT) self-replicating RNA (repRNA) and an adenovirus vector. The composit...

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Main Authors PORTER, Ely Blanton, WEISS, Ron, MELO, Mariane Bandeira, VAN DER NEUT KOLFSCHOTEN, Marijn, VOGELS, Ronald, KITADA, Tasuku, IRVINE, Darrell J
Format Patent
LanguageEnglish
French
German
Published 03.06.2020
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Compositions and methods are described for inducing an immune response against an immunogen in humans. The induced immune response is obtained by administering a heterologous prime-boost combination of an in vitro transcribed (IVT) self-replicating RNA (repRNA) and an adenovirus vector. The compositions and methods can be used to provide a protective immunity against a disease, such as a viral infection or a cancer, in humans.
Bibliography:Application Number: EP20180762177