CD206+ MACROPHAGE-SPECIFIC MOLECULAR IMAGING PROBE COMPOSITIONS AND METHODS AND THE NONINVASIVE QUANTIFICATION OF ARTERIAL WALL MACROPHAGE INFILTRATION IN HUMANS

Described herein are compositions and methods for diagnosing, imaging, and quantifying non-calcified atherosclerotic plaque. Embodiments of compositions described herein comprise mannosylated dextran compounds along with other carbohydrate molecules comprising, for example, a diagnostic agent and a...

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Bibliographic Details
Main Authors ABBRUZZESE, Bonnie Chandler, COPE, Frederick, O, RALPH, David Allen
Format Patent
LanguageEnglish
French
German
Published 15.04.2020
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Described herein are compositions and methods for diagnosing, imaging, and quantifying non-calcified atherosclerotic plaque. Embodiments of compositions described herein comprise mannosylated dextran compounds along with other carbohydrate molecules comprising, for example, a diagnostic agent and a diagnostic moiety. The compounds and methods embodied herein produce superior localization and results for imaging, anatomically locating, and quantifying non-calcified atherosclerotic plaque.
Bibliography:Application Number: EP20180802977