METHOD FOR GENOTYPICALLY IDENTIFYING BOTH ALLELES OF AT LEAST ONE LOCUS OF A SUBJECT'S HLA GENE

• Main Authors: Rosa Ferrer, Ricardo, Gómez Ramos, Alberto, Triviño Pardo, Juan Carlos, Collado Micó, Maria Carmen, Gorriz Belert, Manuel, Bernad Palomares, Lucía, Fernández Pedrosa, María Victoria, Cabo Díez, Miguel, Valero Hervás, Diana María, Buades Gomis, Celia
• Format: Patent
• Language: English; French; German
• Published: 25.03.2020
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; VINEGAR; WINE

The method of the invention enables performing a genetic test on patients in order to learn the haplotypes (combination of alleles at the same loci of a chromosome that are transmitted together) of their human leukocyte antigens (HLA) with a precision, accuracy and improved reliability with respect to the methods known in the state of the art. The invention establishes, by bioinformatic analysis, the precise determination of these haplotypes and enables knowing which individuals are compatible for transplants; diagnosis/prognosis of autoimmune diseases; paternity tests; adverse reactions to drugs in personalised medicine; vaccination, etc.