PYRROLO AND PYRAZOLOPYRIMIDINES AS UBIQUITIN-SPECIFIC PROTEASE 7 INHIBITORS

The invention relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula...

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Main Authors WANG, Minghua, SCHMIDT, Darby Rye, CARAVELLA, Justin A, DIEBOLD, R. Bruce, ERICSSON, Anna, CAMPBELL, Ann-Marie, FOLLOWS, Bruce, BUCKMELTER, Alexandre Joseph, TALBOT, Adam Charles, GUERIN, David Joseph, LANCIA, David R., Jr, IOANNIDIS, Stephanos
Format Patent
LanguageEnglish
French
German
Published 18.03.2020
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula:where m, n, X1, X2, R1-R5, R5'and R6are described herein.
Bibliography:Application Number: EP20190207235