A CONJUGATE OF A TUBULYSIN ANALOG WITH BRANCHED LINKERS

The present invention relates to the conjugation of a tubulysin analog compound to a cell-binding molecule with branched/side-chain linkers for having better delivery of the conjugate compound and targeted treatment of abnormal cells. It also relates to a branched-linkage method of conjugation of a...

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Bibliographic Details
Main Authors ZHAO, Robert Yongxin, LI, Wenjun, GAI, Shun, ZHUO, Xiaotao, ZHENG, Jun, HUANG, Yuanyuan, JIA, Junxiang, YANG, Qingliang, ZHANG, Xiuzheng, CAI, Xiang, ZHOU, Xiaomai, GUO, Huihui, XU, Yifang, LEI, Jun, TONG, Qianqian, ZHAO, Linyao, XIE, Hongsheng, YE, Hangbo, BAI, Lu, CAO, Mingjun
Format Patent
LanguageEnglish
French
German
Published 13.01.2021
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to the conjugation of a tubulysin analog compound to a cell-binding molecule with branched/side-chain linkers for having better delivery of the conjugate compound and targeted treatment of abnormal cells. It also relates to a branched-linkage method of conjugation of a tubulysin analog molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and autoimmune disease.
Bibliography:Application Number: EP20170936036