NEUTRALISING ANTIBODIES TO THE MAJOR EXOTOXIN TCDA OF CLOSTRIDIUM DIFFICILE

This present invention describes the derivation and selection of antibodies capable of neutralising the major exotox-in; TcdA of Clostridium difficile. The invention also describes novel neutralisation and antigen binding properties of in-dividual Mabs and mixtures thereof.

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Bibliographic Details
Main Authors LIGHTWOOD, Daniel John, FISHER, Nicola Louise, MACKENZIE, Brendon, PAGE, Matthew Jon Timothy, TYSON, Kerry Louise, HUMPHREYS, David Paul, COMPSON, Joanne Elizabeth, COX, Matthew, KNIGHT, David Edward Ormonde, HERVÉ, Karine Jeannine Madeleine, PAYNE, Andrew Charles
Format Patent
LanguageEnglish
French
German
Published 04.03.2020
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:This present invention describes the derivation and selection of antibodies capable of neutralising the major exotox-in; TcdA of Clostridium difficile. The invention also describes novel neutralisation and antigen binding properties of in-dividual Mabs and mixtures thereof.
Bibliography:Application Number: EP20190160911