MONOCLONAL ANTIBODY ANTAGONIZING AND INHIBITING BINDING BETWEEN HUMAN PD-1 ANTIGEN AND LIGAND THEREOF, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Disclosed in the present invention is a monoclonal antibody or a derivative thereof which can antagonize and inhibit the binding of human PD-1 antigen to its ligand: the amino acid sequences of CDR1, CDR 2 and CDR 3 in the light chain variable region of the antibody are shown in SEQ ID NO:3, SEQ ID...
Saved in:
Main Authors | , , , , , , , |
---|---|
Format | Patent |
Language | English French German |
Published |
22.11.2023
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Disclosed in the present invention is a monoclonal antibody or a derivative thereof which can antagonize and inhibit the binding of human PD-1 antigen to its ligand: the amino acid sequences of CDR1, CDR 2 and CDR 3 in the light chain variable region of the antibody are shown in SEQ ID NO:3, SEQ ID NO: 4 and SEQ ID NO: 5, respectively, while the amino acid sequences of CDR 1, CDR 2 and CDR 3 in the heavy chain variable region are shown in SEQ ID NO: 8, SEQ ID NO: 9 and SEQ ID NO: 10, respectively. Further disclosed are a humanization preparation process for the antibody and the amino acid sequences of the heavy chain variable region and light chain variable region of the humanized antibody. The antibody or a derivative thereof can be used as a component of pharmaceutical composition or an appropriate pharmaceutic preparation either alone or in combination with other treatments such as chemotherapeutics to cure colon cancer and other solid tumors. |
---|---|
Bibliography: | Application Number: EP20170906230 |