NAPHTHYRIDINES AS INHIBITORS OF HPK1

Naphthyridine compounds and their use as inhibitors of HPK1 are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune resp...

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Main Authors RAJAPAKSA, Naomi, GANCIA, Emanuela, MALHOTRA, Sushant, CARTWRIGHT, Matthew W, ZHOU, Aihe, GOOD, Andrew, GAZZARD, Lewis, SIU, Michael, JONES, Graham, LU, Aijun, DANIELS, Blake, STIVALA, Craig, CHAN, Bryan, TELLIS, John, MENDONCA, Rohan, FAVOR, David, WANG, Weiru, FONG, Kin Chiu, MADIN, Andrew, SEWARD, Eileen, DROBNICK, Joy, LAINCHBURY, Michael, HU, Yonghan, HU, Baihua, HEFFRON, Timothy, LIANG, Jun, WEI, BinQing, HUESTIS, Malcolm
Format Patent
LanguageEnglish
French
German
Published 05.02.2020
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Abstract Naphthyridine compounds and their use as inhibitors of HPK1 are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the naphthyridine compounds.
AbstractList Naphthyridine compounds and their use as inhibitors of HPK1 are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the naphthyridine compounds.
Author DROBNICK, Joy
HU, Baihua
LAINCHBURY, Michael
WEI, BinQing
TELLIS, John
LU, Aijun
JONES, Graham
FONG, Kin Chiu
SIU, Michael
MALHOTRA, Sushant
GANCIA, Emanuela
MADIN, Andrew
MENDONCA, Rohan
RAJAPAKSA, Naomi
FAVOR, David
CARTWRIGHT, Matthew W
DANIELS, Blake
STIVALA, Craig
GOOD, Andrew
HUESTIS, Malcolm
CHAN, Bryan
GAZZARD, Lewis
HEFFRON, Timothy
LIANG, Jun
WANG, Weiru
HU, Yonghan
SEWARD, Eileen
ZHOU, Aihe
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– fullname: MALHOTRA, Sushant
– fullname: CARTWRIGHT, Matthew W
– fullname: ZHOU, Aihe
– fullname: GOOD, Andrew
– fullname: GAZZARD, Lewis
– fullname: SIU, Michael
– fullname: JONES, Graham
– fullname: LU, Aijun
– fullname: DANIELS, Blake
– fullname: STIVALA, Craig
– fullname: CHAN, Bryan
– fullname: TELLIS, John
– fullname: MENDONCA, Rohan
– fullname: FAVOR, David
– fullname: WANG, Weiru
– fullname: FONG, Kin Chiu
– fullname: MADIN, Andrew
– fullname: SEWARD, Eileen
– fullname: DROBNICK, Joy
– fullname: LAINCHBURY, Michael
– fullname: HU, Yonghan
– fullname: HU, Baihua
– fullname: HEFFRON, Timothy
– fullname: LIANG, Jun
– fullname: WEI, BinQing
– fullname: HUESTIS, Malcolm
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DocumentTitleAlternate NAPHTYRIDINES UTILISÉS EN TANT QU'INHIBITEURS DE HPK1
NAPHTHYRIDINE ALS INHIBITOREN VON HPK1
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Snippet Naphthyridine compounds and their use as inhibitors of HPK1 are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an...
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SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title NAPHTHYRIDINES AS INHIBITORS OF HPK1
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