NAPHTHYRIDINES AS INHIBITORS OF HPK1

Naphthyridine compounds and their use as inhibitors of HPK1 are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune resp...

Full description

Saved in:
Bibliographic Details
Main Authors RAJAPAKSA, Naomi, GANCIA, Emanuela, MALHOTRA, Sushant, CARTWRIGHT, Matthew W, ZHOU, Aihe, GOOD, Andrew, GAZZARD, Lewis, SIU, Michael, JONES, Graham, LU, Aijun, DANIELS, Blake, STIVALA, Craig, CHAN, Bryan, TELLIS, John, MENDONCA, Rohan, FAVOR, David, WANG, Weiru, FONG, Kin Chiu, MADIN, Andrew, SEWARD, Eileen, DROBNICK, Joy, LAINCHBURY, Michael, HU, Yonghan, HU, Baihua, HEFFRON, Timothy, LIANG, Jun, WEI, BinQing, HUESTIS, Malcolm
Format Patent
LanguageEnglish
French
German
Published 05.02.2020
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

More Information
Summary:Naphthyridine compounds and their use as inhibitors of HPK1 are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the naphthyridine compounds.
Bibliography:Application Number: EP20180726551