HYPERPOLARISATION IN AQUEOUS MEDIA VIA SABRE

There is described a method for the preparation of an aqueous magnetic resonance imaging medium, said method comprising the steps of: *(i) preparing a multiphasic solvent system comprising an aqueous component and a non-aqueous component, said solvent comprising a target substrate and a SABRE hyperp...

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Bibliographic Details
Main Authors IALI, Wissam, DUCKETT, Simon Benedict, OLARU, Alexandra Maria
Format Patent
LanguageEnglish
French
German
Published 24.07.2024
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEASURING
MEASURING ELECTRIC VARIABLES
MEASURING MAGNETIC VARIABLES
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PHYSICS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
TESTING
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Summary:There is described a method for the preparation of an aqueous magnetic resonance imaging medium, said method comprising the steps of: *(i) preparing a multiphasic solvent system comprising an aqueous component and a non-aqueous component, said solvent comprising a target substrate and a SABRE hyperpolarisation transfer catalyst; *(ii) adding H2 or parahydrogen gas; *(iii) agitating the solvent system to form an emulsion thereby transferring the spin order from the hyperpolarisation transfer catalyst to the target substrate; *(v) adding a solvent phase-separation promoter; and *(vi) separating the non-aqueous component and the aqueous component wherein the aqueous component contains the hyperpolarised target substrate and provides the aqueous magnetic resonance imaging medium.
Bibliography:Application Number: EP20180717651