METHODS OF ENGINEERING HUMAN INDUCED PLURIPOTENT STEM CELLS TO PRODUCE LIVER TISSUE

Methods are disclosed herein for producing human hepatocytes from human induced pluripotent stem cells. Also provided are transgenic rats for the expansion of human hepatocytes, such as those produced using the methods disclosed herein.

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Bibliographic Details
Main Authors SOTO-GUTIERREZ, Alejandro, TAKEISHI, Kazuki, MASHIMO, Tomoji, POPOVIC, Branimir, HANDA, Kan, WANG, Yang, COLLIN DE I'HORTET, Alexandra, Sylvie, LEPE, Jorge, Guzman, ALVAREZ, Eduardo, Cervantes
Format Patent
LanguageEnglish
French
German
Published 16.12.2020
Subjects
AGRICULTURE
ANIMAL HUSBANDRY
BEER
BIOCHEMISTRY
CARE OF BIRDS, FISHES, INSECTS
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
FISHING
FORESTRY
HUMAN NECESSITIES
HUNTING
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
NEW BREEDS OF ANIMALS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR
SPIRITS
TRAPPING
VINEGAR
WINE
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Summary:Methods are disclosed herein for producing human hepatocytes from human induced pluripotent stem cells. Also provided are transgenic rats for the expansion of human hepatocytes, such as those produced using the methods disclosed herein.
Bibliography:Application Number: EP20180754542