TREATMENT OF CD47+ DISEASE CELLS WITH SIRP ALPHA-FC FUSIONS

A human SIRPα fusion protein useful to inhibit the growth and/or proliferation of a CD47+ disease cell, the fusion protein having negligible CD47 agonism and negligible red blood cell binding, the fusion protein comprising a human SIRPα domain effective to bind human CD47 with an affinity that is at...

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Bibliographic Details
Main Authors PANG, Xinli, SLAVOVA-PETROVA, Penka Slavtcheva, UGER, Robert Adam
Format Patent
LanguageEnglish
French
German
Published 13.04.2022
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
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Summary:A human SIRPα fusion protein useful to inhibit the growth and/or proliferation of a CD47+ disease cell, the fusion protein having negligible CD47 agonism and negligible red blood cell binding, the fusion protein comprising a human SIRPα domain effective to bind human CD47 with an affinity that is at least five fold greater than the affinity of the entire extracellular region of human SIRPα, and a human IgG constant region (Fc) having effector function, the potency of the fusion protein being at least 5 fold greater than the potency of a SIRPαFc fusion formed from an Fc region lacking effector function, wherein the human SIRPα domain is an IgV domain comprising residues 32-137 [SEQ ID No.1] of human SIRPα variant 2.
Bibliography:Application Number: EP20190185175