CYCLIC DINUCLEOTIDES AS STING AGONISTS

Disclosed are compounds, compositions and methods for treating of diseases, syndromes, or disorders that are affected by the modulation of STING. Such compounds are represented by Formula (I) as follows:wherein R, R1B, R1C, R2B, R2C, B1, W, X, Y, Z are defined herein.

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Bibliographic Details
Main Authors EMANUEL, Stuart, BEIGELMAN, Leonid, VIELLEVOYE, Marcel, EDWARDS, James Patrick, SCHEPENS, Wim, ZHONG, Minghong, WANG, Guangyi, BIGNAN, Gilles, THURING, Johannes Wilhelmus John Fitzgerald, RICHTER, Mark, CONNOLLY, Peter J, THATIKONDA, Santhosh Kumar
Format Patent
LanguageEnglish
French
German
Published 01.06.2022
Subjects
CHEMISTRY
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SUGARS
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Summary:Disclosed are compounds, compositions and methods for treating of diseases, syndromes, or disorders that are affected by the modulation of STING. Such compounds are represented by Formula (I) as follows:wherein R, R1B, R1C, R2B, R2C, B1, W, X, Y, Z are defined herein.
Bibliography:Application Number: EP20180703858